2010 Mercedes-Benz E350 problems & reliability
183 owner complaints filed with NHTSA for the 2010 Mercedes-Benz E350, alongside 4 safety recall campaigns. Last verified Aug 7, 2026. Complaints are unverified reports submitted by owners to the federal Office of Defects Investigation.
Each complaint is counted once (by NHTSA case number), even when it names several vehicles.
5 complaints report injuries (6 injured).
Most reported problems
| Component | Complaints | Share |
|---|---|---|
| Air Bags | 68 | 37% |
| Unknown OR Other | 19 | 10% |
| Fuel/propulsion System | 18 | 10% |
| Electrical System | 17 | 9% |
| Suspension | 17 | 9% |
| Engine | 15 | 8% |
| Power Train | 14 | 8% |
| Service Brakes | 11 | 6% |
| Structure | 11 | 6% |
| Steering | 7 | 4% |
Component groups as classified by NHTSA. A complaint can name more than one component, so shares may sum to more than 100%.
Common symptoms owners describe
Keyword analysis of complaint narratives; one complaint can describe several symptoms.
Mileage when problems occurred
Half of the failures with a reported odometer reading occurred by 65,000 miles (middle 50% between 35,850 and 94,000 miles), based on 73 complaints that included mileage.
Complaints by incident year
What owners report
“I am writing to formally submit a complaint regarding my 2010 E350 (VIN # [XXX] ). I have taken great pride in owning and maintaining this vehicle, and I want to share my concerns based on my recent experience. I have consistently kept this car well-maintained, following all recommended service schedules and ensuring…”
Service Brakes · filed Apr 10, 2026
“All of sudden blind spot inoperable , turning signal to Rt. , signal goes LT. OR TURNING SIGNAL TO LT. , SIGNAL GOES To RT.”
Exterior Lighting · filed Feb 17, 2026
“Car was found to have the rear subframe corrosion for issue. But also the brake lines were corroded very badly. They should be covered under the rear subframe extended warranty replacement. The rear brake lines are an frequent issue and almost always shows up when the subframe begins to rot. Also the pattern of the…”
Structure · filed Jan 19, 2026
Verbatim excerpts from complaints filed with NHTSA. Reports are not independently verified.
Federal defect investigations
- Desiccated Air Bag Inflator Rupture
Engineering Analysis EA21002 · opened Sep 17, 2021 · open
- Rear brake line failure
Defect Petition DP20004 · opened Apr 24, 2020 · closed Oct 9, 2020
Technical service bulletins
180 manufacturer communications (TSBs, service campaigns, warranty extensions) are on file with NHTSA for the 2010 Mercedes-Benz E350. The 10 most recent:
Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The noise is heard once in each instance when changing direction of travel. Note: Sound file in attachment Cause…
LI35.30-P-058566 · Service Bulletin/Repair Instructions · issued Jul 14, 2026
Complaint The underfloor paneling is loose or sags (picture 1). Cause Mounting clips broken or not correctly engaged. Remedy Replace all mounting clips with collar nuts with shims (picture 2): Adapter set (203 589 02 31…
LI61.25-P-047933 · Service Bulletin/Repair Instructions · issued Jun 2, 2026
Complaint After successful commissioning of the HERMES control unit (N112/9) with XENTRY Diagnosis DVD 03/2026, the message "SOS - service not activated" appears on the instrument cluster. In addition, the following two…
LI82.85-P-080507 · Service Bulletin/Repair Instructions · issued May 26, 2026
Complaint There are several types of complaint about noises or poor windshield wiper wiping performance: A: Wiper blades squeaking, chattering, shuddering B: The windshield is not wiped completely (streaking) C: During…
LI82.30-P-059239 · Service Bulletin/Repair Instructions · issued May 19, 2026
Complaint Potential corrosion on the rear axle carrier Cause Due to market-specific conditions such as moisture, ingress of dirt and/or environmental influences, corrosion can occur on the rear axle carrier Remedy In…
LI35.10-P-078931 · Service Bulletin/Repair Instructions · issued May 13, 2026
Complaint Headlamp, front fog lamp leaky or fogged. Cause Fogging of the headlamps is a natural phenomenon, which can occur under certain climatic conditions. It does not lead to any technical impairment of the…
LI82.10-P-078301 · Service Bulletin/Repair Instructions · issued Apr 16, 2026
Complaint Headlamp, front fog lamp leaky or fogged Cause Fogging of the headlamps is a natural phenomenon, which can occur under certain climatic conditions. It does not lead to any technical impairment of the headlamp…
LI82.10-P-078301 · Service Bulletin/Repair Instructions · issued Mar 9, 2026
Complaint Headlamps leaking or fogged Cause The fogging of the headlamp is a natural phenomenon which can occur under certain climatic conditions. In contrast to a leaky headlamp, physical fogging does not result in a…
LI82.10-P-078307 · Service Bulletin/Repair Instructions · issued Feb 25, 2026
Complaint Headlamp, front fog lamp leaky or fogged Cause Fogging of the headlamps is a natural phenomenon, which can occur under certain climatic conditions. It does not lead to any technical impairment of the headlamp…
LI82.10-P-078301 · Service Bulletin/Repair Instructions · issued Feb 24, 2026
Complaint Headlamps leaking or fogged Cause The fogging of the headlamp is a natural phenomenon which can occur under certain climatic conditions. In contrast to a leaky headlamp, physical fogging does not result in a…
LI82.10-P-078896 · Service Bulletin/Repair Instructions · issued Feb 24, 2026
TSBs are repair guidance manufacturers send to dealers — they are not recalls and repairs are not automatically free. Full documents are available on NHTSA’s site.
Safety recalls
The 2010 Mercedes-Benz E350 has 4 NHTSA recall campaigns — recall repairs are free at franchised dealers regardless of the vehicle’s age.
Check whether your specific vehicle is affected
Recall campaigns often cover only certain VIN ranges. Enter your VIN on the official NHTSA site to confirm whether your vehicle is included and whether the repair is still open.
Check VIN on NHTSA →Buying a used 2010 Mercedes-Benz E350?
- · Decode the seller’s VIN with our free VIN decoder to confirm the exact year, engine and trim.
- · Check for unrepaired recalls by VIN on NHTSA’s official lookup — recall repairs are free.
- · Owners most often reported problems around 65,000 miles — budget accordingly if the car is approaching that mileage.