2010 Mercedes-Benz E350 power train problems
14 owner complaints filed with NHTSA name the power train on the 2010 Mercedes-Benz E350 — 8% of all complaints for this model year.
What owners report
“Car shifts into park when I stop, does not happen all the time, no check engine light, no warning, don't know it shifted until I try to move forward. last time I drove the car it did it as I was stopping, made a funny grind noise, no warning lights or bells will contact dealer. this is very…”
filed Feb 27, 2022
“The contact owns a 2010 Mercedes-Benz E350. The contact stated that while driving at an undisclosed speed, the transmission shifted to PARK before the vehicle came to a full stop. The vehicle was taken to the dealer and diagnosed that the failure was related to TSB - LI54.25-P-056472. The contact…”
filed Feb 18, 2022
Verbatim excerpts from complaints filed with NHTSA. Reports are not independently verified.
Related service bulletins
Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The noise is heard once in each instance when changing direction of travel. Note: Sound file in attachment Cause…
LI35.30-P-058566 · Service Bulletin/Repair Instructions · issued Jul 14, 2026
Power Train problems in other E350 years
| Year | Reports | Share |
|---|---|---|
| 2016 E350 | 5 | 10% |
| 2015 E350 | 1 | 3% |
| 2014 E350 | 15 | 5% |
| 2013 E350 | 7 | 4% |
| 2012 E350 | 10 | 5% |
| 2011 E350 | 6 | 3% |
| 2009 E350 | 2 | 3% |
| 2008 E350 | 5 | 3% |
| 2007 E350 | 21 | 6% |
| 2006 E350 | 37 | 9% |
Other reported problem areas on the 2010 Mercedes-Benz E350
Counts are unique NHTSA complaints naming this component group. Complaints are unverified owner reports; mileage is computed only from complaints that included a usable odometer reading.