2006 Mercedes-Benz E500 problems & reliability
50 owner complaints filed with NHTSA for the 2006 Mercedes-Benz E500, alongside 4 safety recall campaigns. Last verified Aug 7, 2026. Complaints are unverified reports submitted by owners to the federal Office of Defects Investigation.
Each complaint is counted once (by NHTSA case number), even when it names several vehicles.
1 complaint report injuries (1 injured).
Most reported problems
| Component | Complaints | Share |
|---|---|---|
| Fuel/propulsion System → | 16 | 32% |
| Fuel System, Gasoline → | 15 | 30% |
| Air Bags | 4 | 8% |
| Wheels | 4 | 8% |
| Electrical System | 3 | 6% |
| Suspension | 3 | 6% |
| Power Train | 2 | 4% |
| Service Brakes | 2 | 4% |
| Steering | 2 | 4% |
| Electronic Stability Control (esc) | 1 | 2% |
Component groups as classified by NHTSA. A complaint can name more than one component, so shares may sum to more than 100%.
Mileage when problems occurred
Half of the failures with a reported odometer reading occurred by 80,000 miles (middle 50% between 66,250 and 103,750 miles), based on 42 complaints that included mileage.
Complaints by incident year
What owners report
“The contact owns a 2006 Mercedes-Benz E500. The contact stated that while driving at an undisclosed speed, the contact became aware of a fuel leak, and the check engine warning light was illuminated. A diagnostic test revealed an Evaporative Emissions (EVAP) control system leak. The vehicle was not taken to a dealer…”
Fuel System, Gasoline · filed Mar 11, 2026
“My father and mother were driving back home on the evening of 1/29/25 when all of a sudden they heard a loud pop/explosion and their seat belts tightened. They were traveling at a speed of approximately 35 mph on local roads. There was no accident, collision, or warning signs, but the driver's side airbags, left side…”
Air Bags · filed Jan 31, 2025
“The contact owns a 2006 Mercedes-Benz E 500. The contact stated that while driving at unknown speeds, she noticed arrows were pointing at the sunroof. The contact stated that the failure was due to NHTSA Campaign Number: 22V954000 (Visibility). The vehicle was taken to the local dealer but was not diagnosed or…”
Visibility · filed Oct 17, 2024
Verbatim excerpts from complaints filed with NHTSA. Reports are not independently verified.
Federal defect investigations
- Fuel Leakage From The Fuel Tank
Engineering Analysis EA13003 · opened Mar 15, 2013 · closed Dec 19, 2014
- Driver Air Bag Circuit High Resistance
Preliminary Evaluation PE10017 · opened May 14, 2010 · closed Nov 24, 2010
Technical service bulletins
94 manufacturer communications (TSBs, service campaigns, warranty extensions) are on file with NHTSA for the 2006 Mercedes-Benz E500. The 10 most recent:
Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The noise is heard once in each instance when changing direction of travel. Note: Sound file in attachment Cause…
LI35.30-P-058566 · Service Bulletin/Repair Instructions · issued Jul 14, 2026
Complaint There are several types of complaint about noises or poor windshield wiper wiping performance: A: Wiper blades squeaking, chattering, shuddering B: The windshield is not wiped completely (streaking) C: During…
LI82.30-P-059239 · Service Bulletin/Repair Instructions · issued May 19, 2026
Complaint Headlamp, front fog lamp leaky or fogged. Cause Fogging of the headlamps is a natural phenomenon, which can occur under certain climatic conditions. It does not lead to any technical impairment of the…
LI82.10-P-078301 · Service Bulletin/Repair Instructions · issued Apr 16, 2026
Complaint Headlamp, front fog lamp leaky or fogged Cause Fogging of the headlamps is a natural phenomenon, which can occur under certain climatic conditions. It does not lead to any technical impairment of the headlamp…
LI82.10-P-078301 · Service Bulletin/Repair Instructions · issued Mar 9, 2026
Complaint Headlamps leaking or fogged Cause The fogging of the headlamp is a natural phenomenon which can occur under certain climatic conditions. In contrast to a leaky headlamp, physical fogging does not result in a…
LI82.10-P-078307 · Service Bulletin/Repair Instructions · issued Feb 25, 2026
Complaint Headlamps leaking or fogged Cause The fogging of the headlamp is a natural phenomenon which can occur under certain climatic conditions. In contrast to a leaky headlamp, physical fogging does not result in a…
LI82.10-P-078896 · Service Bulletin/Repair Instructions · issued Feb 24, 2026
Complaint Customer states the AC either does not cool/has poor performance or heat is insufficient. Cause Many possible root causes Remedy AC Diagnosis (General) Initial Steps Verify Customer Concern • Confirm the issue…
LI83.30-P-079850 · Service Bulletin/Repair Instructions · issued Jan 7, 2026
Complaint Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The clunk is heard once when changing from forward to reverse (and vice versa). Note: Sound file in…
LI33.30-P-056665 · Service Bulletin/Repair Instructions · issued Nov 15, 2025
Complaint Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). The clunk is heard once when changing from forward to reverse (and vice versa). Note: Sound file in…
LI33.30-P-056665 · Service Bulletin/Repair Instructions · issued May 21, 2025
Complaint Headlamps leaking or fogged Cause The fogging of the headlamp is a natural phenomenon which can occur under certain climatic conditions. In contrast to a leaky headlamp, physical fogging does not result in a…
LI82.10-P-078896 · Service Bulletin/Repair Instructions · issued Apr 28, 2025
TSBs are repair guidance manufacturers send to dealers — they are not recalls and repairs are not automatically free. Full documents are available on NHTSA’s site.
Safety recalls
The 2006 Mercedes-Benz E500 has 4 NHTSA recall campaigns — recall repairs are free at franchised dealers regardless of the vehicle’s age.
Check whether your specific vehicle is affected
Recall campaigns often cover only certain VIN ranges. Enter your VIN on the official NHTSA site to confirm whether your vehicle is included and whether the repair is still open.
Check VIN on NHTSA →Buying a used 2006 Mercedes-Benz E500?
- · Decode the seller’s VIN with our free VIN decoder to confirm the exact year, engine and trim.
- · Check for unrepaired recalls by VIN on NHTSA’s official lookup — recall repairs are free.
- · Owners most often reported problems around 80,000 miles — budget accordingly if the car is approaching that mileage.