2021 Ford E-350 engine problems

11 owner complaints filed with NHTSA name the engine on the 2021 Ford E-350 — 50% of all complaints for this model year.

Engine complaints

50%

share of all complaints

—

median reported incident mileage

0 / 0

crash / fire reports

What owners report

“Engine misfire on a 2021 Ford E-350 cutaway, 7.3L V8, used for parcel delivery. The vehicle was delivered to Ford of Spartanburg (Ford dealership) for diagnosis. The vehicle is still out of service. Ford's diagnosis, Repair Order 593079, June 26, 2026: "WILL NEED TO REPLACE ALL SPARK PLUGS AND…”
filed Sep 13, 2026
“Engine failure on a 2021 Ford E-350 cutaway, 7.3L V8, used for parcel delivery. The vehicle was taken out of service and has not run since. Two diagnoses, both in writing. ACME Mobile Service, July 27, 2026, at 152,760 miles: "Found the #5 cylinder is completely disabled and dropped out. Truck will…”
filed Sep 13, 2026
“Engine failure at 78,172, excess wear to the camshaft lobes and valve tappet surface. We have had 22 failures. There was a recall -24B27 for 2021 and 2022 models year for idle oil pressure. Most vans had 70 to 80k on them by the time we received a letter. Some engine have been changed twice. Ford has a serious problem…”
filed Nov 28, 2025

Verbatim excerpts from complaints filed with NHTSA. Reports are not independently verified.

Some 2021-2026 F-150 vehicles equipped with a 5.0L/5.2L engine, 2021-2025 F-Super Duty/F-53 Motorhome/F59 Commercial Stripped Chassis vehicles equipped with a 6.8L/7.3L engine and 2021-2025 E-Series/F-650/F-750 vehicles…
SSM 54678 · Service Bulletin/Repair Instructions · issued Mar 20, 2026
This article supersedes TSB 25-2322 to update the Service Procedure, Labor Operations and Parts List. Some of the vehicles listed in the Model statement above may exhibit an upper engine ticking or tapping noise at…
TSB 25-2572 · Service Bulletin/Repair Instructions · issued Nov 26, 2025